31 Mar 2018. Just days before the release of his latest film, 'Harajuku Hollywood', [Shivrajkumar] is today in Madhapur.. Shingu. How about your favourite movie from the last 10 years?.
Jun 2, 2018. Then I saw the movie 'Harajuku Hollywood' and I was.. [Shiva Ramkumar], the 'actor', has always wanted to act.. What a good movie!.. I saw the movie 'Harajuku Hollywood' recently and I can truly say, I wasn't disappointed..Harmonic synthesis on the airway smooth muscle cell.
Harmonic synthesis in the airway smooth muscle cell was studied using the membrane excitability recordings. The excitability changes to the agonists were measured in the presence of selective antagonists. The application of acetylcholine (ACh) at 0.1-1 microM for 20-30 s showed an initial excitatory response followed by a depression in the response. The application of ACh at 1 microM for more than 40 s evoked a sustained outward current. Both the excitatory and the sustained outward currents were antagonized by atropine. However, the application of ACh for 60 s evoked a sustained outward current and a depolarizing membrane potential shift that were completely antagonized by pirenzepine. The current and the membrane potential shift evoked by ACh could be followed by the application of histamine at 10 nM for 30 s. The inward current and the depolarizing potential shift induced by histamine were also antagonized by pirenzepine. These results indicate that the sustained outward current is mediated by muscarinic receptors and the membrane depolarization is mediated by histamine receptors. There is some evidence that the excitatory response and the sustained outward current induced by ACh were mediated by P2y receptors and the inward current induced by histamine was mediated by P2x receptors. These receptors may coexist on the cell membrane to mediate the excitatory response and the inward current induced by histamine.