Tight blood glucose control reduces the risk of long-term diabetes related complications [16, 17] but is limited by hypoglycaemia . Insulin analogues and modern insulin regimens, including insulin pump therapy, have lowered the relative risk of hypoglycaemia compared with those observed in the intensive insulin treatment group of the transformative Diabetes Control and Complication Trial [16, 19, 20] but inherent unpredictability and variability of glucose levels remains a significant barrier. Glucose-responsive insulin delivery by closed-loop systems addresses these unmet clinical needs and aims to reduce the burden of diabetes care.
Methods: Using 6-minute resting-state functional MRI, we compared PAG-FC between 32 TTH subjects (23 females), during pain-free state and 32 healthy controls (21 females) using Statistical Parametric Mapping (SPM12) toolbox in MATLAB.
Methods: Ninety-one headache-free episodic migraine patients and 73 controls underwent RS functional magnetic resonance imaging. Twenty-three patients and 23 controls were re-examined after 4 years. A seed-based correlation approach was used to study hypothalamic and pontine RS FC changes, separately.
Methods: We conducted a randomized, double blind, sham-controlled, multicenter study at 10 sites in the United States. 538 adults diagnosed with 2-8 migraine headache days per month were randomized to active or sham stimulation. Neurostimulation was applied for a 2-hour, continuous session. Migraine pain levels and most bothersome migraine-associated symptom (MBS) were recorded at baseline, 2 hours and 24 hours using a paper diary. The primary endpoints for the study were pain freedom at 2 hours and freedom from the MBS at 2 hours. The secondary endpoints were pain relief at 2 hours, absence of all most bothersome migraine-associated symptoms (MBSs) at 2 hours, acute medication use within 24 hours after treatment, sustained pain freedom at 24 hours and sustained pain relief at 24 hours.
Results: All participants were male; mean age was 48.2±8 in the control group and 50.2±10.9 in the patient group. Patients had had an attack free period of at least 1 month (mean attack free period 9.5±12.9 months). We found no differences in RMET (p=0.152), HADS Anxiety score (p=0.107) nor HADS Depression score (p=0.530). We found differences in Hinting task (p=0.006) and SDMT (p=0.001).
Methods: Migraine patients were prospectively enrolled, with the diagnosis made according to the ICHD criteria by headache specialists. DNA samples of 3,502 population controls free of stroke, dementia, and headache were obtained from the Taiwan Biobank. Genotyping of p.R544C was carried out by TaqMan genotyping assay or Axiom Genome-Wide TWB 2.0 Array. 2b1af7f3a8