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"The harder the erection, the healthier the man." Is the penis a barometer of a man's health? Steven Lamm, MD, says that great sex can only come with great health and that once men understand the connection between health and virility, they will take better care of themselves. For men who want to achieve peak sexual health -- and the partners who love them -- Lamm shared his advice for health and hardness on July 13, 2005.
MEMBER QUESTION: I'm 42 and I want to know if there are exercises to improve blood flow and strengthen erection. Another concern of mine is the loss of sensation around the head of my penis during intercourse that keeps me from being able to ejaculate. Does this have anything to do with hardness?
MODERATOR: You talk about something in your book called the "4-Day Insurance Policy." It even says: Open only in case of emergency. The Hardness Factor 4-Day Insurance Policy enhances hardness in only four days. You look at it as an emergency kind of program, but I looked at it and thought perhaps this would give someone a sample of what they can do if they actually stuck with the program long term.
I think that women can basically appreciate that sexuality and an erection is a very, very important aspect of a man's being. She has to really understand that very, very clearly. And, she must appreciate that there is a link between the man's health and the quality of his erection. That can be a motivating force when the woman says, "Look, I have noticed that there is kind of a change in either your interest in sex or in the actual hardness of your penis and I'm concerned about your health. I read Dr. Lamm's book and I think this can be fixed. Sex is as important for me as it is for you, so I'd like to make an appointment with the doctor for you and I'd like you to read the book. I'd like you to start to make some changes."
We show that unless $\NP \subseteq \RTIME (2^{\poly(\log{n})})$,there is no polynomial-time algorithm approximating the ShortestVector Problem ($\SVP$) on $n$-dimensional lattices in the $\ell_p$norm ($1 \leq p0$. This improves theprevious best factor of $2^{(\log{n})^{1/2-\eps}}$ under the samecomplexity assumption due to Khot (J. ACM, 2005). Under thestronger assumption $\NP \nsubseteq \RSUBEXP$, we obtain a hardnessfactor of $n^{c/\log\log{n}}$ for some $c>0$.
Our proof starts with Khot's $\SVP$ instances that are hard toapproximate to within some constant. To boost the hardness factorwe simply apply the standard tensor product of lattices. The mainnovel part is in the analysis, where we show that the lattices ofKhot behave nicely under tensorization. At the heart of theanalysis is a certain matrix inequality which was first used in thecontext of lattices by de Shalit and Parzanchevski.
The carbon-nitrogen (C-N) system was long believed to have materials harder than diamond1. Recently, carbon nitrides attracted attention due to their potential applications in photocatalysis2, photodegradation3 and photoelectrochemical anticorrosion4 technology. However, studies of carbon nitrides under pressure face a big problem: neither from theory, nor from experiment it is clear which compositions (i.e., which C/N ratios) will be stable at high pressure and which compositions will have optimal properties, such as hardness.
Hardness is one of the biggest factors that stimulated interest in carbon nitrides. To study their hardness, we have used the Oganov34,35, Šimůnek36 and Gao37 models that are based on microscopic parameters and the Chen model38 which is based on macroscopic parameters. All the results, including the Voigt-Reuss-Hill elastic moduli, are listed in Tables 1 and 2.
Based on the macroscopic Chen model, the hardest structure is Cmc21-C3N4 (Table 2). The hardness value in this model is determined by parameter k2G (k = G/B, G and B are shear and bulk moduli, respectively). We found that the Cmc21-C3N4 structure has the largest k2G among the stable structures (Table 2). This makes the Cmc21-C3N4 structure the hardest one among the stable structures according to the Chen model. Notably, the predicted Poisson's ratio of the Cmc21-C3N4 structure is 0.1348, almost the lowest among all the stable structures (v = 0 means that the material will not deform in a direction perpendicular to the applied load). According to the Chen model, all the stable structures are superhard, which is consistent with the prediction of the microscopic models. While the exact hardness values produced by the microscopic and macroscopic models are in this case rather different (which is unusual), the qualitative conclusions are similar. Note, on passing, that the bulk modulus of cubic-C3N4 is larger than that of diamond, in good agreement with theoretical studies21,22.
Hard water is usually defined as water, which contains a high concentration of calcium and magnesium ions. However, hardness can be caused by several other dissolved metals; those forms divalent or multivalent cations, including aluminum, barium, strontium, iron, zinc, and manganese. Normally, monovalent ions such as sodium and potassium do not cause hardness. These divalent cations have a propensity to come together with anions in the water to form stable salts. The type of anion found in these salts distinguishes between the two types of hardness-carbonate and non-carbonate hardness [Table 1].
Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.
In this review we will address the current data about bone cells biology, bone matrix, and the factors that influence the bone remodeling process. Moreover, we will briefly discuss the role of estrogen on bone tissue under physiological and pathological conditions.
Osteoblasts are derived from mesenchymal stem cells (MSC). The commitment of MSC towards the osteoprogenitor lineage requires the expression of specific genes, following timely programmed steps, including the synthesis of bone morphogenetic proteins (BMPs) and members of the Wingless (Wnt) pathways [25]. The expressions of Runt-related transcription factors 2, Distal-less homeobox 5 (Dlx5), and osterix (Osx) are crucial for osteoblast differentiation [22, 26]. Additionally, Runx2 is a master gene of osteoblast differentiation, as demonstrated by the fact that Runx2-null mice are devoid of osteoblasts [26, 27]. Runx2 has demonstrated to upregulate osteoblast-related genes such as ColIA1, ALP, BSP, BGLAP, and OCN [28].
The secretory activity of bone lining cells depends on the bone physiological status, whereby these cells can reacquire their secretory activity, enhancing their size and adopting a cuboidal appearance [52]. Bone lining cells functions are not completely understood, but it has been shown that these cells prevent the direct interaction between osteoclasts and bone matrix, when bone resorption should not occur, and also participate in osteoclast differentiation, producing osteoprotegerin (OPG) and the receptor activator of nuclear factor kappa-B ligand (RANKL) [14, 53]. Moreover, the bone lining cells, together with other bone cells, are an important component of the BMU, an anatomical structure that is present during the bone remodeling cycle [9].
The RANKL/RANK interaction also promotes the expression of other osteoclastogenic factors such as NFATc1 and DC-STAMP. By interacting with the transcription factors PU.1, cFos, and MITF, NFATc1 regulates osteoclast-specific genes including TRAP and cathepsin K, which are crucial for osteoclast activity [90]. Under the influence of the RANKL/RANK interaction, NFATc1 also induces the expression of DC-STAMP, which is crucial for the fusion of osteoclast precursors [91, 92].
Despite these osteoclastogenic factors having been well defined, it has recently been demonstrated that the osteoclastogenic potential may differ depending on the bone site considered. It has been reported that osteoclasts from long bone marrow are formed faster than in the jaw. This different dynamic of osteoclastogenesis possibly could be, due to the cellular composition of the bone-site specific marrow [93].
Furthermore, there is evidence that osteoclasts display several other functions. For example, it has been shown that osteoclasts produce factors called clastokines that control osteoblast during the bone remodeling cycle, which will be discussed below. Other recent evidence is that osteoclasts may also directly regulate the hematopoietic stem cell niche [112]. These findings indicate that osteoclasts are not only bone resorbing cells, but also a source of cytokines that influence the activity of other cells. 2b1af7f3a8
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